abstract |
This invention provides compounds and methods for treating, with said compound, a mycobacterial infection by administering to an animal a pharmaceutical composition containing a compound having the formula R—SO n -Z-CO—Y, where R is an alkyl groups having 6-20 carbon atoms, unsaturated hydrocarbon groups having 6-20 carbon atoms, or alkyl groups having 6-20 carbon atoms interrupted by at least one aromatic ring; Z is —CH 2 —, —CH 2 CH 2 —, —NH—NH—, —O—, ——NH—, —O—NH—, —CH 2 —NH—, —CH 2 —O—, —NH—O—, —NH—CH 2 —, —O—CH 2 —, and —CH═CH—; Y is —NH 2 , —O—CH 2 —C 6 H 5 , —CO—CO—O—CH 3 , and —O—CH 3 ; and n is 1 or 2. It has been discovered that these compounds treat microbially-based infections caused by corynebacteria, nocardiae, rhodococcus, and mycobacteria. These compounds may be used to treat mycobacterial cells, such as Mycobacteria tuberculosis , drug resistant M. tuberculosis, M. avium intracellulare, M. leprae, M. paratuberculosis , and pathogenic Mycobacteria sp. |