| Predicate |
Object |
| assignee |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_f3ebf63d28f804e0a154cf8da0ccf2c6 |
| classificationCPCAdditional |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/Y02A40-146
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/Y10S930-13 |
| classificationCPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N9-18
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K14-415
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N9-14
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N15-8242
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N15-8286 |
| classificationIPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N15-82
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N15-29
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N9-18
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N9-14
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07K14-415 |
| filingDate |
2007-06-28-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate |
2008-06-03-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_41a94ea7a3c65b5d082615f7b97c1e5e
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_bcfea3f633b4219c998ecc1fec43d58a
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_aff30f4649bb4a4fe246c49111552fb4
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_9614b057c5bb74982ef0220fbaa34dff |
| publicationDate |
2008-06-03-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber |
US-7381556-B2 |
| titleOfInvention |
Nucleic acids encoding deallergenized proteins and permuteins |
| abstract |
Modified proteins are disclosed that maintain enzymatic and insecticidal activity while displaying reduced or eliminated allergenicity. Epitopes which bind to anti-patatin antibodies were identified, and removed via site directed mutagenesis. Tyrosines were observed to generally contribute to the allergenic properties of patatin proteins. Removal of glycosylation sites was observed to reduce or eliminate antibody binding. Permuteins are also disclosed which have a rearranged amino acid sequence while retaining enzymatic activity. Deallergenized proteins and permuteins can be used as insecticidal materials, as nutritional supplements, and as immunotherapeutic agents. |
| priorityDate |
2000-01-06-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type |
http://data.epo.org/linked-data/def/patent/Publication |