| Predicate |
Object |
| assignee |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_eb141b396e502bfce986c491d722e401 |
| classificationCPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/G01N33-505
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12Q1-485 |
| classificationIPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12Q1-48
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/G01N33-50
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K49-00 |
| filingDate |
2005-01-10-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate |
2008-06-03-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_f46a3ebbcb6bd8ac9b39126085caa1b6 |
| publicationDate |
2008-06-03-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber |
US-7381401-B2 |
| titleOfInvention |
T cell anergy is reversed by active Ras and regulated by diacylglycerol kinase |
| abstract |
T cell anergy has been correlated with defective Ras signaling. However, neither a causal relationship nor the mechanism of Ras hypoactivation have been established. Using adenoviral transduction of CAR Tg T cells to enable genetic manipulation in nonproliferating cells, we show that Ras61L restores IL-2 production and MAP kinase signaling in T cells anergized in vitro or in vivo. A gene array screen revealed upregulated diacylglycerol kinase (DGK) in the anergic state, which was confirmed by RT-PCR and Western blot analysis. A DGK inhibitor significantly restored IL-2 production by anergic cells. Our data support a causal role for DGK and defective Ras signaling in T cell anergy. |
| isCitedBy |
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-2021132422-A1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-10954238-B1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/KR-20220119702-A
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-2022114164-A1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-11713316-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-10669272-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-2015224142-A1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-11584747-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/KR-20230116838-A
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-9937205-B2 |
| priorityDate |
2004-01-08-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type |
http://data.epo.org/linked-data/def/patent/Publication |