| abstract |
A fatty acid analogue of the general formula: R 1 -[x i -CH 2 ] n —COOR 2 , wherein R 1 is: a C 2 -C 24 alkene with one or more double bonds and/or with one or more triple bonds, and/or a C 2 -C 24 alkyne, and/or a C 1 -C 24 alkyl, or a C 1 -C 24 alkyl substituted in one or several positions with one or more compounds selected from the group comprising fluoride, chloride, hydroxy, C 1 -C 4 alkoxy, C 1 -C 4 alkylthio, C 2 -C 5 acyloxy or C 1 -C 4 alkyl, and wherein R2 represents hydrogen or C 1 -C 4 alkyl, and wherein n is an integer from 1 to 12, and wherein i is an odd number and indicates the position relative to COOR 2 , and wherein X i independent of each other are selected from the group comprising O, S, SO, SO 2 , Se and CH 2 , and with the proviso that at least one of the X i is not CH 2 , and or a salt, prodrug or complex thereof is used in the treatment and/or prevention of primary and secondary metastatic neoplasms. |