http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-7375248-B2
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_27a71ddaaa2f5a8c228fc6cb3f3b3098 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D213-42 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07C311-08 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P37-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P37-02 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P29-00 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C229-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D213-42 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A01N37-12 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A01N37-34 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C315-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P37-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C311-08 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P29-00 |
| filingDate | 2004-06-16-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 2008-05-20-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_872438192affd0a4ca04c8e3d71543b2 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_afbf9251aa58445d3b0c75ea0afe743f |
| publicationDate | 2008-05-20-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | US-7375248-B2 |
| titleOfInvention | Inhibitors of matrix metalloproteinase |
| abstract | Compounds of formula (I): n nwhereinn R 1 represents optionally substituted C 4-12 alkyl, optionally substituted C 2-6 alkylaryl, or optionally substituted 5- or 6-membered aryl or heteroaryl; Z represents a bond, CH 2 , O, S, SO, SO 2 , NR 4 , OCR 4 R 5 , CR 4 R 5 O, or Z, R 1 and Q together form an optionally substituted fused tricyclic group; Q represents an optionally substituted 5- or 6-membered aryl or heteroaryl ring; X represents COR 3 or N(OR 8 )COR 9 ; R 2 represents SO 2 R 10 or SO 2 NR 10 R 11 ; R 3 represents OR 6 , NR 6 R 7 or NR 6 OH; R 4 and R 5 each independently represents H, C 1-6 alkyl or C 1-4 alkylaryl; R 6 and R 7 each independently represents H, C 1-6 alkyl, or C 1-6 alkyl substituted with one or more heteroaryl groups, or R 6 and R 7 together with the nitrogen atom to which they are attached form a 5- or 6-membered ring which may optionally include 1 or more further heteroatoms selected from O, S and N; R 8 and R 9 each independently represents H or C 1-6 alkyl; R 10 and R 11 each independently represents H or C 1-6 alkyl; andn nand physiologically functional derivatives thereof, with the exception of N-(ethoxycarbonyl)-N-[4-(1H-tetrazol-1-yl)phenyl]glycine, processes for their preparation, pharmaceutical formulations containing them and their use as inhibitors of matrix metalloproteinase enzymes (MMPs) are described. |
| isCitedBy | http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-8343986-B2 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-7601729-B2 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-2010029699-A1 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-2006293353-A1 |
| priorityDate | 2003-06-20-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 434.