| abstract |
Compounds and their use as pharmaceuticals particularly as Raf kinase inhibitors for the treatment of neurotraumatic diseases, cancer, chronic neurodegeneration, pain, migraine and cardiac hypertrophy. Wherein X is O, CH 2 CO, S or NH, or the moiety X—R 1 is hydrogen; Y 1 and Y 2 independently represent CH or N; Ar is a mono- or fused bicyclic aromatic or heteroaromatic group which may be optionally substituted; one of X 1 and X 2 is selected from O, S or NR 11 and the other is CH, wherein R 11 is hydrogen, C 1-6 alkyl, aryl or arylC 1-6 alkyl. |