| abstract |
An affinity ligand-matrix conjugate comprises the matrix and conjugated thereto by the group Z, a ligand having general formula (I): n nwherein one X is N and the other X is N, CCL or CCn; A 1 and A 2 are each independently O, S or N—R 1 and R 1 is H, C 1-6 alkyl, C 1-6 hydroxyalkyl, benzyl or β-phenylethyl; B 1 and B 2 are each independently an optionally substituted hydrocarbon linkage containing from 1 to 10 carbon atoms; D 1 is H or a primary amino, secondary amino, tertiary amino, quaternary ammonium, imidazole, guanidine or amidino group; and D 2 is a secondary amino, tertiary amino, quaternary ammonium, imidazole, guanidine or amidino group; or B 2 —D 2 is —CHCOOH—(CH 2 ) 3-4 —NH 2 ; and p is 0 or 1. Such conjugates are useful for the separation, isolation, purification, characterization, identification or quantification of an endotoxin. |