abstract |
A highly selective melanocortin-4 receptor antagonist cyclic peptide of the formula n nwhere R 1 , R 2 , R 3 , R 4a , R 4b , R 5 , R 6 , R 7 , x, y and z are as defined in the specification, and a method of treating body weight disorders, including cachexia, sarcopenia and wasting syndrome or disease, and treating inflammation and immune disorders. |