http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-7332592-B2
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_cea139ad438b9ce7d33159d45b154c6b |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K14-70596 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07H21-02 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07H21-04 |
| filingDate | 2005-06-03-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 2008-02-19-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_ebedc63b3607390e69326d77ad02ab97 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_41c29a9c1ec8ca7b237a9bcc1a4b7c06 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_7a783701e504bf6e798b9d4140451fcd |
| publicationDate | 2008-02-19-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | US-7332592-B2 |
| titleOfInvention | Isolated recombinant bovine soluble CD14 polypeptide, rbosCD14 |
| abstract | Studies in mice and humans indicate that membrane CD14 (mCD14) on the cell surface of monocytes, macrophages, and PMN mediates the activation of these cells by LPS. The soluble CD14 (sCD14) present in the circulation also binds to LPS and blocks LPS binding to mCD14. To determine the role of a recombinant bovine soluble CD14 polypeptide in cellular activation by LPS, a recombinant bovine soluble CD14 polypeptide, rbosCD14, was cloned and expressed in a baculovirus expression system. Results indicated that rbosCD14 inhibited the LPS-induced increase in CD18 expression and TNFα mRNA in vitro and reduced mortality in mice injected with LPS. Further, rbosCD14 sensitized mammary epithelial cells to low concentrations of LPS resulting in recruitment of white blood cells and prevention of LPS-induced infection. |
| priorityDate | 2002-06-27-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 639.