| Predicate |
Object |
| assignee |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_b5dd388a5130b0bdede0fdfc6c2af6ed |
| classificationCPCAdditional |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12Q2600-106
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/G01N2333-82 |
| classificationCPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N9-12
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12Q1-485
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12Q1-6886
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K14-82
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/G01N33-57426 |
| classificationIPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12Q1-68
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N9-20
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N1-20
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07K14-82
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N15-00 |
| filingDate |
2006-09-20-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate |
2008-02-05-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_6c1a90b0f4b04ab504569d2d807497f6
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_a874dd87b7b373e57a4d2fba3a5e6ee2 |
| publicationDate |
2008-02-05-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber |
US-7326534-B2 |
| titleOfInvention |
Detection of gleevec resistant mutations |
| abstract |
The present invention relates to isolated polypeptides which comprise an amino acid sequence consisting of a mutated functional Abl kinase domain, said mutated functional kinase domain being resistant to inhibition of its tyrosine kinase activity by N-[4-methyl-3-(4-pyridin-3-yl-pyrimidin-2-ylamino)-phenyl]-4-(4-methyl-piperazin-1-ylmethyl)-benzamide or a salt thereof, to the use of such polypeptides to screen for compounds which inhibit the tyrosine kinase activity of such polypeptides, to nucleic acid molecules encoding such polypeptides, to recombinant vectors and host cells comprising such nucleic acid molecules and to the use of such nucleic acid molecules in the production of such polypeptides for use in screening for compounds which inhibit the tyrosine kinase activity of such polypeptides. |
| isCitedBy |
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-2006269956-A1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-2010055687-A1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-8586291-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-9994910-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-2011065107-A1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-9056924-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-8697348-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-2012282622-A1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-2010248241-A1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-9085644-B2 |
| priorityDate |
2001-10-05-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type |
http://data.epo.org/linked-data/def/patent/Publication |