| abstract |
The present invention relates to compounds of formula I: n nor a pharmaceutically acceptable acid addition salt thereof, where;n X is —C(R 4 )═ or —N═; Ar is phenyl, substituted phenyl, heterocycle, or substituted heterocycle; R 1 and R 2 are independently hydrogen or C 1 -C 3 alkyl; R 3 is hydrogen, fluoro, or methyl; when X is —C(R 4 )═,R 4 is hydrogen, fluoro, or methyl, provided that no more than one of R 3 and R 4 may be other than hydrogen; and R 5 is hydrogen, methyl, or ethyl. The compounds of the present invention are useful for activating 5 -HT 1F receptors, inhibiting dural protein extravasation, and for the treatment or prevention of migraine in a mammal. |