http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-7294707-B2
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_f97f0fa258a008bf056ad04b7f380dda |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K1-003 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07K1-113 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07K1-08 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07K14-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07K1-00 |
| filingDate | 2004-10-06-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 2007-11-13-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_dc4bba6c1e4b8f74e7c567afb7aa880e http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_f9416e456e1df4c1ddcdca03a9437bb3 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_3051c9d3341978c5c0dbacc7cadddcf1 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_596141ea1b7c70c89e25dc074d0258d7 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_879be0b535adfdfbd962f08a65183d5d http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_8bdee5fbf6cfbbd21998dc1b8fd679f9 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_56ae695af7f3d69fe85e4706a464fb38 |
| publicationDate | 2007-11-13-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | US-7294707-B2 |
| titleOfInvention | Method for modifying protein or peptide C-terminal |
| abstract | A simple and low-cost method of selectively modifying the C-terminal of a protein or peptide is provided. A method of modifying the C-terminal of a protein or peptide comprises forming an intramolecular oxazolone ring at the C-terminal of the protein or peptide that requires C-terminal modification, and then performing a ring-opening of the oxazolone ring to produce a protein or peptide with a modified C-terminal. Preferred forms include a method in which by reacting the oxazolone ring with a compound containing a nucleophilic group to effect an oxazolone ring-opening, a protein or peptide is produced in which the C-terminal is modified with the compound containing the nucleophilic group, as well as a method in which by reacting the oxazolone ring with an active esterifying agent to effect a ring-opening, the oxazolone is converted to an active ester, which by subsequent reaction with a compound containing a nucleophilic group, produces a protein or peptide in which the C-terminal has been modified with the compound containing the nucleophilic group. |
| isCitedBy | http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-2022026438-A1 |
| priorityDate | 2003-10-17-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 93.