http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-7291601-B1
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_a4e304884a957f1ac9db793d2c6b7d9d http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_b5b9f9cd8f41ddd9b8e5bc26a4d68518 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P35-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P19-02 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K38-08 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K7-06 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K38-08 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07K7-06 |
| filingDate | 1999-12-21-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 2007-11-06-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_10d449a7b4892bf71e7df3c1cef832d1 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_75617a6feac35baeadf805a8945d8ccb http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_3da5005acc5b3360d511ff2700ebb898 |
| publicationDate | 2007-11-06-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | US-7291601-B1 |
| titleOfInvention | Arginine-rich anti-vascular endothelial growth factor peptides that inhibit growth and metastasis of human tumor cells by blocking angiogenesis |
| abstract | Disclosed are novel peptides inhibitory of the activity of vascular endothelial growth factor (VEGF) and their use in the treatment of angiogenesis-related diseases, including cancer. A combinatorial library of peptides consisting of six amino acid residues were chemically synthesize and, from the library, specific amino acid residues for each amino acid position were screened by comparing their inhibitory activity against VEGF binding to the cell surface receptor. The novel peptide sequences thus obtained bind to VEGF and block the binding of VEGF to its receptors present on the surface of vascular endothelial cells, thereby inhibiting the hormonal activity of VEGF. The peptides inhibit the angiogenesis induced by VEGF and human cancer cells. Also, the peptides inhibit growth and metastasis of human cancer cells transplanted to mice. Thus, the peptides can be used to treat angiogenesis-related diseases, including cancer, diabetic retinopathy, rheumatoid arthritis, etc. |
| isCitedBy | http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-2013216564-A1 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-2010005527-A1 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-9504738-B2 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-10308943-B2 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-11162083-B2 |
| priorityDate | 1999-12-21-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 52.