| Predicate |
Object |
| assignee |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_42dcb8afd289e295b65f450020cbfdb4 |
| classificationCPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12Q1-6897 |
| classificationIPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12Q1-68
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07H21-04
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07H21-02 |
| filingDate |
2003-06-23-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate |
2007-11-06-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_7b34aea3cc446c7847c4e23270f6b057
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_926c66ff102e98cf303e3b3937199b37 |
| publicationDate |
2007-11-06-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber |
US-7291461-B2 |
| titleOfInvention |
Methods for identifying small molecules that modulate premature translation termination and nonsense mRNA decay |
| abstract |
The present invention relates to methods for identifying compounds that modulate premature translation termination and/or nonsense-mediated mRNA decay by screening and identifying compounds that modulate the post-transcriptional expression of any gene with a premature translation stop codon. The invention particularly relates to using any gene encoding a premature stop codon to identify compounds that modulate premature translation termination and/or nonsense-mediated mRNA decay. A compound that modulates premature translation termination and/or nonsense-mediated mRNA decay of a target gene is identified using standard methods known in the art to measure changes in translation or mRNA stability of the gene product or mRNA of the gene with the premature stop codon. The methods of the present invention provide a simple, sensitive assay for high-throughput screening of libraries of compounds to identify pharmaceutical leads. |
| isCitedBy |
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-2009241203-A1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-2009235368-A1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-9241976-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-9488655-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-9487575-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-2006257866-A1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-2015182545-A1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-9775854-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-7989675-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-2011027894-A1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/JP-WO2014141847-A1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-7927791-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-9034645-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-9110083-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-2006134681-A1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-8912386-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-2010081151-A1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-2009154999-A3
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-10208103-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-8618352-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-2011088102-A1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-10555960-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-8323915-B2 |
| priorityDate |
2002-06-21-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type |
http://data.epo.org/linked-data/def/patent/Publication |