| Predicate |
Object |
| assignee |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_d6bb8f4f5cdb954257aca660eb17b948 |
| classificationCPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K47-544 |
| classificationIPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A01N37-18 |
| filingDate |
2005-02-28-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate |
2007-10-23-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_1d1805ca5deab387a7df9976f27ea25f |
| publicationDate |
2007-10-23-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber |
US-7285529-B2 |
| titleOfInvention |
Embedder compositions and methods for detecting and killing cells in acidic areas of tumors |
| abstract |
Embedder compositions effective for detecting or killing cells in acidic areas of tumors are described. Each composition includes an embedder peptide which at pH 7.2 and above is poly-anionic and so repels from cells in normal tissues, but at lower pH in hypoxic areas of tumors the embedder peptide converts to a non-ionic lipophilic form effective to embed into membranes of cells. Each composition also includes a cargo component which cannot be pulled across cell membranes by the embedder peptide and which is effective for detecting or killing cells in whose membranes the embedder peptide has embedded. |
| isCitedBy |
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-7589169-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-2008124274-A1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-2006239924-A1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-8084610-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-8231859-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-2006093660-A1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-2007286803-A1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-2005260259-A1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-8257682-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-2010158806-A1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-7790140-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-8277776-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-2010221184-A1 |
| priorityDate |
2005-02-28-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type |
http://data.epo.org/linked-data/def/patent/Publication |