| abstract |
The present invention provides a phosphonic acid diester compound represented by General Formula n nwherein R 1 , R 2 , R 3 and R 4 are the same or different, and represent hydrogen, halogen, lower alkyl or lower alkoxy; R 5 is phenyl having on the phenyl ring 1–3 substituents selected from the group consisting of lower alkyl, halogen-substituted lower alkyl, lower alkoxy, halogen-substituted lower alkoxy, phenoxy, benzyloxy, hydroxyl, halogen, nitro, lower alkylthio, di(lower alkyl)amino, lower alkanolyamino, pyrrolidinyl and phenyl, or the like, provided that R 5 is not mono(lower alkoxy)pheny; and R 6 is lower alkyl;n nand an ACAT-1 inhibitor containing the compound as an active ingredient. |