http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-7259142-B2
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_61f88efcda59d7062a4252ecf6886f58 |
| classificationCPCAdditional | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K38-00 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K7-56 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K7-06 |
| classificationIPCAdditional | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K38-00 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K38-12 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07K7-06 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07K7-56 |
| filingDate | 2005-09-13-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 2007-08-21-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_0923040936f55316cffe7c5da40a0b17 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_d0bf33b7d738f3d5ba23de5d4a9dbc28 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_af0f9e393284ca2f1f6c8dc5071833e8 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_18bb940024632742c89e487562b97010 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_42675a510409445656786c53253ef999 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_ff229925a5f21ff99a3db944c1ea7749 |
| publicationDate | 2007-08-21-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | US-7259142-B2 |
| titleOfInvention | Redox-stable, non-phosphorylated cyclic peptide inhibitors of SH2 domain binding to target protein, conjugates thereof, compositions and methods of synthesis and use |
| abstract | A compound of formula: n n n n n n n n n n n n in which (i) aa 1 is Adi and aa 4 is Glu or (ii) each of aa 1 and aa 4 is Adi, L is sulfur, sulfoxide, oxygen or methylene, which compound (and its conjugates) bind to an SH2 domain in a protein comprising an SH2 domain, is non-phosphorylated, is redox-stable in vivo, is characterized by an IC 50 in vivo of less than about 4.0 μM with respect to the SH2 domain in Grb2, and, upon binding to the SH2 domain of Grb2, has a turn conformation. A conjugate comprising a compound as described above and a carrier agent, a composition comprising (i) a compound or a conjugate as described above and (ii) a carrier, a method of inhibiting binding of an SH2 domain in a protein comprising an SH2 domain to a target protein in an animal, wherein the SH2 domain is contacted with a target protein-binding inhibiting effective amount of a compound or a conjugate as described above, and a method of synthesizing such conjugates. |
| isCitedBy | http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-2008031812-A1 |
| priorityDate | 1999-06-02-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 184.