| abstract |
The invention provides the compounds of formula (I) n n nand pharmaceutically acceptable derivatives thereof wherein:n R 0 and R 1 are independently selected from the group consisting of H, halogen, C 1-6 alkyl, C 1-6 alkoxy, and C 1-6 alkoxy substituted by one or more fluorine atoms; R 2 is selected from the group consisting of H, C 1-6 alkyl, C 1-6 alkyl substituted by one or more fluorine atoms, C 1-6 alkoxy, C 1-6 hydroxyalkyl, SC 1-6 alkyl, C(O)H, C(O)C 1-6 alkyl, C 1-6 alkylsulphonyl, and C 1-6 alkoxy substituted by one or more fluorine atoms; and R 3 is C 1-6 alkyl or NH 2 . nn Compounds of formula (I) are potent and selective inhibitors of COX-2 and are of use in the treatment of the pain, fever, inflammation of a variety of conditions and diseases. |