| Predicate |
Object |
| assignee |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_a722744e77c81c5f5cf415087e2ee92b |
| classificationCPCAdditional |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A01K2217-075
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A01K2227-105
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K2039-505
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K48-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A01K2267-03
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A01K2267-0368
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K2319-30
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K2317-76
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A01K2217-05 |
| classificationCPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K16-2803
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K16-2896
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K16-2845
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/G01N33-5047
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N15-8509
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K38-177
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A01K67-0276 |
| classificationIPCAdditional |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K48-00 |
| classificationIPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K39-395
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07K16-28
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/G01N33-50
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N15-85 |
| filingDate |
2001-03-13-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate |
2007-05-29-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_d1e2bd3f673a195b6dab63efdb59ed97
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_331436be3cab1ded084d2071c04818fe |
| publicationDate |
2007-05-29-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber |
US-7223395-B2 |
| titleOfInvention |
Blocking leukocyte emigration and inflammation by interfering with CD99/HEC2 |
| abstract |
The present invention provides methods and compositions for modulating transendothelial migration (TEM) of leukocytes. In particular, inhibition of TEM can provide a potent therapeutic approach to treating inflammatory conditions. The invention specifically relates to the discovery that CD99 mediates TEM, because blocking CD99 on either endothelial cells or monocytes bloks migration 80-90%. In conjunction with PECAM inhibitors, TEM blockade approaches 100%. CD99 is involved in a step in TEM that is distal to the step controlled by PECAM. |
| isCitedBy |
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-8436207-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-9901625-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-8937193-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-2009052443-A1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-2008213279-A1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-8487131-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-2009105319-A1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-8088382-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-2011112112-A1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-9115061-B2 |
| priorityDate |
2000-03-13-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type |
http://data.epo.org/linked-data/def/patent/Publication |