abstract |
The present invention describes novel 1,3-dihydro-imidazol-2-one or 1,3-dihydro-imidazol-2-thione compounds of formula (I): n nor a stereoisomer or pharmaceutically acceptable salt or solvate thereof, wherein A, L R 1 , R 2 , R 3 and R 4 are defined in the present specification, which are useful as selective inhibitors of MMP, TACE, aggrecanase or a combination thereof. This invention also relates to pharmaceutical compositions comprising these compounds and methods of using the same. |