http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-7208608-B2
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_5305109c4efec4cbcdd8bc05bdb00399 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D207-337 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D207-34 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07F3-04 |
| classificationIPCAdditional | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D207-32 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D207-34 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D207-337 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D207-335 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D207-416 |
| filingDate | 2003-01-30-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 2007-04-24-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_a9823889dd90f9c9a56c2e9403b99c16 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_c93253feb793680b8124284c539bfb2b |
| publicationDate | 2007-04-24-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | US-7208608-B2 |
| titleOfInvention | Method of manufacturing an amorphous form of the hemi-calcium salt of (3R,5R) 7-3-phenyl-4-phenylcarbamoyl-2-(4-fluorophenyl)-5-isopropyl-pyrrol-1-yll-3, 5-dihydroxyheptanoic acid (actorvastatin) |
| abstract | A method of manufacturing an amorphous form of the hemi-calcium salt of (3R, 5R) 7-[3-phenyl-4-phenylcarbamoyl-2-(4-fluorophenyl)-5-isopropyl-pyrrol-1-yl]-3,5-dihydroxyheptanoic acid of formula (I), in which (3R, 5R) 7-[3-phenyl-4-phenylcarbamoyl-2-(4-fluorophenyl)-5-isopropyl-pyrrol-1-yl]-3,5-dihydroxyheptanoic acid or its salt with a cation M + wherein M 30 is either a cation of an alkali metal or an ammonium cation of formula R n N (+) H (4−n) wherein R is lower C 1 –C 5 alkyl, n may reach values ranging between 0 and 3, is, without isolating the intermediate in the form of the hemi-calcium salt or of another salt, acid or lactone, converted, in a solution, by the treatment with the calcium salt or calcium hydroxide, or a calcium C 1 –C 5 alcoholate, to the hemi-calcium salt, and the latter is precipitated with a C 1 –C 5 hydrocarbon or dialkylether of formula R 1 OR 2 , wherein each of R 1 and R 2 is a C 1 –C 5 alkyl group. The starting acid or its salt is prepared starting from (3R, 5R) tert-butyl (6-{2-[3-phenyl-4-phenylcarbamoyl-2-(4-fluorophenyl)-5-isopropyl-pyrrol-1-yl]-ethyl}-2,2-dimethyl-[1,3]dioxane-4-yl) acetate of formula II. |
| isCitedBy | http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-8367848-B2 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-2010056605-A1 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-2010190999-A1 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-2011088806-A2 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-2006287538-A1 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-8115015-B2 |
| priorityDate | 2002-02-01-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 146.