| Predicate |
Object |
| assignee |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_96eddd31165955882708d73c89118259 |
| classificationCPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P29-02
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P35-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P43-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D487-04 |
| classificationIPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D521-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D487-04 |
| filingDate |
2006-05-22-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate |
2007-03-20-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_3ff41189a52c1d01f2e5793ceabbf101 |
| publicationDate |
2007-03-20-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber |
US-7193079-B1 |
| titleOfInvention |
Preparation of hymenialdisine derivatives and use thereof |
| abstract |
The synthesis and biological activity of indoloazepines and acid amine salts thereof which are structurally related to naturally-occurring hymenialdisine is disclosed. Naturally-occurring hymenialdisine obtained from the sponge is a potent inhibitor of production of cytokines interleukin-2 (IL-2) and tumor necrosis factor-α (TNF-α). The chemically-synthesized indoloazepines of the invention also inhibit production of IL-2 and TNF-α. The indoloazepines are useful for treating inflammatory diseases, particularly diseases associated with kinases NF-κB or GSK-3β activation or NF-κB activated gene expression products. The indoloazepines are useful for the treatment of cancer by the inhibition of kinases CHK1 and CHK2. |
| isCitedBy |
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-8618299-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-8629158-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-8637501-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-2010203113-A1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-2009275590-A1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-9650378-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-9296743-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-8716308-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-2010331339-A9
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-2011003737-A1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-2011003738-A1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-2011003739-A1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-2011003793-A1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-8697700-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-8304408-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-8993765-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-9073925-B2 |
| priorityDate |
2003-05-19-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type |
http://data.epo.org/linked-data/def/patent/Publication |