| abstract |
Compounds of general formula (I): in which: R 1 is hydrogen, C 1 –C 20 alkyl, C 3 –C 10 cycloalkyl, C 4 –C 20 cycloalkylalkyl, aryl, arylalkyl, or two R1, taken together, form a straight or cyclic C 2 –C 10 alkylene group or an ortho disubstituted arylene; R 2 is hydrogen, C 1 –C 20 alkyl, C 3 –C 10 cycloalkyl, C 4 –C 20 cycloalkylalkyl, aryl or aryl alkyl optionally substituted with functional groups which allow conjugation with a suitable molecule able to interact with physiological systems; R 3 , R 4 and R 5 are hydrogen, C 1 –C 20 alkyl, C 3 –C 10 cycloalkyl, C 4 –C 20 cycloalkylalkyl, aryl, arylalkyl; and their chelates with bi-trivalent ions of the metal elements having atomic number ranging between 20 and 31, 39, 42, 43, 44, 49, and between 57 and 83, and radioisotopes chosen among 203 Pb 67 Ga 68 Ga 72 As 111 In 113 In 90 Y 97 Ru 62 Cu 64 Cu 52 Fe 52m Mn 140 La 175 Yb 153 Sm 166 Ho 149 Pm 177 Lu 142 Pr 159 Gd 212 Bi 47 Sc 149 Pm 67 Cu, 111 Ag, 199 Au, 161 Tb and 51 Cr as well as the salts thereof with physiologically compatible bases or acids |