| Predicate |
Object |
| assignee |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_61f88efcda59d7062a4252ecf6886f58 |
| classificationCPCAdditional |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A01K2217-05 |
| classificationCPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K14-47 |
| classificationIPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07K14-47
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N15-12
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07K14-705 |
| filingDate |
2002-05-03-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate |
2007-02-27-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_0d866c626ec5cd50e682719a12e01081
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_71d565db00cd3defade7e5e9b6b82525
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_af455e94470079583479bd4374573196
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_0f1a6c2e25235f2b6f08a0418073c205 |
| publicationDate |
2007-02-27-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber |
US-7183377-B2 |
| titleOfInvention |
Human FRP and fragments thereof including methods for using them |
| abstract |
The invention provides a novel, secreted protein that contains a region homologous to ligand binding domain of a cytokine receptor. This protein, called Frizzled-related protein (FRP), antagonizes the signaling of the Wnt family of cytokines. Extracellular signaling molecules such as the Wnt family members have essential roles as inducers of cellular proliferation, migration, differentiation, and tissue morphogenesis. As Wnt molecules are known to participate in the aberrant growth associated with neoplasia, Wnt antagonists such as FRP are valuable tools which both for understanding oncogenesis and for the design of new cancer therapies. |
| isCitedBy |
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-9579361-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-2017053807-A2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-9573998-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-9732139-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-9987357-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-9273139-B2 |
| priorityDate |
1997-05-29-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type |
http://data.epo.org/linked-data/def/patent/Publication |