| abstract |
Histone deacetylase inhibitors and uses thereof are provided that have the general formula n n n n n n n n n n n n wherein n R 1 , R 2 , R 3 and R 4 are each independently selected from the group consisting of hydrogen, a substituted or unsubstituted straight chained C 1-12 alkyl, C 2-12 aminoalkyl or C 2-12 oxaalkyl, and a substituted and unsubstituted 3, 4, 5, 6, 7 or 8 membered ring, with the proviso that R 3 and R 4 are not both hydrogen; n R 5 is selected from the group consisting of a carbonyl, a substituted or unsubstituted C 1-3 alkyl, a substituted or unsubstituted —C 1-3 alkyl-C(O), a substituted or unsubstituted —C(O)—C 1-3 alkyl, and a substituted or unsubstituted —C(O)C(O)C 1-3 alkyl; n M is a substituent capable of complexing with a protein metal ion; and n L is a substituent comprising a chain of 3–12 atoms connecting the M substituent to the carbon atom alpha to the L substituent. |