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filingDate 1997-12-03-04:00^^<http://www.w3.org/2001/XMLSchema#date>
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inventor http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_290a3e7a0f1085c5881bc54426c919b8
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publicationDate 2006-11-21-04:00^^<http://www.w3.org/2001/XMLSchema#date>
publicationNumber US-7138510-B1
titleOfInvention Cloning sequencing and characterization of two cell death genes and uses therefor
abstract Described herein are genes shown to be essential for programmed cell death in C. elegans , their encoded products (RNA and polypeptides), antibodies directed against the encoded polypeptides; probes for identifying structurally related genes and bioassays for identifying functionally related cell death genes from various organisms; methods and agents for altering (increasing or decreasing) the activity of the cell death-genes and, thus, of altering cell death; and uses therefor. Specifically, two genes shown to be essential for almost all of the cell deaths which occur in the development of C. elegans , referred to as ced-3 and ced-4, have been cloned, sequenced and characterized.
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