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filingDate 2003-09-04-04:00^^<http://www.w3.org/2001/XMLSchema#date>
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publicationNumber US-7138507-B2
titleOfInvention Method of determining a chemotherapeutic regimen based on glutathione-s transferase pi expression
abstract The present invention relates to prognostic methods which are useful in medicine, particularly cancer chemotherapy. The object of the invention to provide a method for assessing GST-pi expression levels in fixed or fixed and paraffin embedded tissues and prognosticate the probable resistance or sensitivity of a patient's tumor to treatment with platinum-based therapies by examination of the amount of GST-pi mRNA in a patient's tumor cells and comparing it to a predetermined threshold expression level. More specifically, the invention provides to oligonucleotide primer pair GST-piand methods comprising their use for detecting levels of GST-pi mRNA.
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