abstract |
The present invention provides an aspartic proteinase-inhibiting compound of the formula: n nwherein a, b, c, d, and e, can be the same or different and each are R 7 , OR 7 , SR 7 , NR 7 R 8 , NHCOR 7 , CO 2 R 7 , CN, NO 2 , NH 2 , N 3 , or a halogen, wherein R 7 and R 8 are independently H or an alkyl. Substituents R 1 or R 2 are each H or an alkyl. Substituent R 3 is a straight chain or branched alkyl, alkenyl, or alkynyl substituent, or is a cycloalkyl. Substituent A is OH, NH 2 , or SH.n n Further provided are pharmaceutical compositions, which include a therapeutically effective amount of at least one of the foregoing compounds, and therapeutic methods of using the foregoing compounds. |