| Predicate |
Object |
| assignee |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_ff81a650b70e913d3b2524b45e4c7320 |
| classificationCPCAdditional |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K48-00 |
| classificationCPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/G01N33-6872
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/G01N33-5061
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/G01N33-502
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K38-1709
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/G01N33-5008 |
| classificationIPCAdditional |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K48-00 |
| classificationIPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/G01N33-50
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K38-17
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12Q1-68
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/G01N33-68 |
| filingDate |
2001-07-03-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate |
2006-10-17-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_c3f91908449eaf6d8aa518ba361d4cd4
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_0fdcdc82004e9f170e4669522a81bcdf
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_7a420ba53716fa3057bbf2d354d738f3
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_4ece02663e4f84cc9ea6666469434773 |
| publicationDate |
2006-10-17-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber |
US-7122307-B2 |
| titleOfInvention |
High throughput biological heart rate monitor that is molecularly determined |
| abstract |
This invention provides for a chamber and system designed for use in assaying drug effects on heart rate. The chamber consists of a series of wells. Cardiac myocytes disaggregated from neonatal animals are plated onto the bottom of each well and grown under standard tissue culture conditions. When drugs are to be assayed, the cells in each well are loaded with a calcium sensitive dye and the beating rate in each is monitored with a photodiode. A drug is added in graded concentrations to each well, and equilibrated and effects on rate are observed. This construct permits use of a cell based bioassay for the study of drugs or agents that may alter cardiac rate. This invention can be used in high throughput screening of drugs to evaluate/predict their effects on cardiac rate and rhythm. |
| isCitedBy |
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-2004254134-A1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-2010011407-A2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-2007048284-A1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-2009175790-A1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-2011077702-A1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-2011189719-A1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-8003618-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-2007042347-A1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-2008181871-A1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-11629318-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-2010011407-A3
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-11384328-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-2009304588-A1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-8748181-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-2004204376-A1 |
| priorityDate |
2001-06-06-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type |
http://data.epo.org/linked-data/def/patent/Publication |