Predicate |
Object |
assignee |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_1bde28565d28f037e78bf4a67776ee24 |
classificationCPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P25-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D307-87 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P25-24 |
classificationIPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D307-78 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-343 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D307-87 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D307-93 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P25-24 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C253-30 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D- http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07B57-00 |
filingDate |
2002-06-25-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
grantDate |
2006-09-26-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
inventor |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_c75f07838a8a23c74523afb6436a2ab3 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_02a02a19757b09826fc9edcc59ae2d0d http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_6de0bdef9525ad196766fbeee40d6e6a http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_43fc5453eed0303c8855cf03ba558bab http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_07a691965dbbf09af93f80a97787406e http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_06aaa115a337a8db3547a0bd861cf9f8 |
publicationDate |
2006-09-26-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
publicationNumber |
US-7112686-B2 |
titleOfInvention |
Process for the preparation of racemic citalopram and/or S-or R-citalopram by separation of a mixture of R-and S-citalopram |
abstract |
The invention relates to a process for the preparation of racemic citalopram free base or an acid addition salt thereof and/or R- or S-citalopram as the free base or an acid addition salt thereof by separation of a mixture of R- and S-citalopram with more than 50% of one of the enantiomers into a fraction consisting of racemic citalopram and/or a fraction of S-citalopram or R-citalopram characterized in that i) citalopram is precipitated from a solvent as the free base or as an acid addition salt thereof; ii) the precipitate formed is separated from the mother liquor; iia) if the precipitate is crystalline it is optionally recrystallised one or more times to form racemic citalopram, and then optionally converted into an acid addition salt thereof; iib) if the precipitate is not crystalline, steps i) and ii) are optionally repeated until a crystalline precipitate is obtained and the crystalline precipitate is recrystallised one or more times to form racemic citalopram, and then optionally converted into an acid addition salt thereof; iii) the mother liquor is optionally subjected to further purification and S-citalopram or R-citalopram is isolated from the mother liquor and optionally converted into an addition salt thereof. |
isCitedBy |
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-2010249437-A1 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-2009069582-A1 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-2008177096-A1 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-8022232-B2 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-7989645-B2 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-7964742-B2 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-2005154052-A1 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-7790935-B2 |
priorityDate |
2001-06-25-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
type |
http://data.epo.org/linked-data/def/patent/Publication |