abstract |
2,4-Dioxo-3-quinazolinylaryl sulfonylurea compounds having the formula: n nwhereinn R is a member selected from the group consisting of H and C 1-6 alkyl; R 1 is a member selected from the group consisting of H, C 1-6 alkyl, C 1-6 haloalkyl, C 3-5 cycloalkyl and C 3-5 cycloalkyl-alkyl; R 2 is a member selected from the group consisting of H, halogen, C 1-6 alkyl, C 2-6 alkenyl, C 2-6 alkynyl, C 1-6 haloalkyl, C 1-6 alkoxy, cyano and —C(O)R 2a , wherein R 2a is a member selected from the group consisting of C 1-6 alkoxy and (C 1-6 alkyl) 0-2 amino; L is a 1 to 3 carbon linking group selected from the group consisting of —CH 2 —, —CH(CH 3 )—, —CH 2 CH 2 —, —CH 2 CH(CH 3 )— and —CH 2 CH 2 CH 2 —; L 1 is a linking group selected from the group consisting of a bond and —CH 2 —; L 2 is a linking group selected from the group consisting of a bond, —NH— and —CH 2 —; and Ar 1 is an aromatic ring selected from the group consisting of benzene, pyridine and pyrimidine;n nare provided. The compounds are useful for the inhibition of ADP-platelet aggregation, particularly in the treatment of thrombosis and thrombosis related conditions or disorders. |