Predicate |
Object |
assignee |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_f9c9410104fff84049bb17df9d762a53 |
classificationCPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-7088 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C08G65-333 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C08G63-91 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C08G65-48 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P29-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K47-58 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K47-60 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K47-6901 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P43-00 |
classificationIPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D249-08 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N9-96 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C08F8-30 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K47-48 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C08F16-06 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C08G65-325 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C08F116-06 |
filingDate |
2003-12-02-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
grantDate |
2006-09-05-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
inventor |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_8583b5594608c546b2c13291ed508711 |
publicationDate |
2006-09-05-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
publicationNumber |
US-7101932-B2 |
titleOfInvention |
Method for the preparation of 1-benzotriazolyl carbonate esters of poly (ethylene glycol) |
abstract |
The invention provides a method for preparing a 1-benzotriazolylcarbonate ester of a water-soluble and non-peptidic polymer by reacting a terminal hydroxyl group of a water-soluble and non-peptidic polymer with di(1-benzotriazolyl)carbonate in the presence of an amine base and an organic solvent. The polymer backbone can be poly(ethylene glycol). The 1-benzotrialylcarbonate ester can then be reacted directly with a biologically active agent to form a biologically active polymer conjugate or reacted with an amino acid, such as lysine, to form an amino acid derivative. |
isCitedBy |
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-7977427-B2 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-2011237746-A1 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-10456476-B2 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-7544738-B2 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-8816002-B2 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-7723432-B2 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-8563651-B2 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-2008227872-A1 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-9346917-B2 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-2010197806-A1 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-9839695-B2 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-2018064822-A1 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-8299173-B2 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-10584181-B2 |
priorityDate |
1999-12-22-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
type |
http://data.epo.org/linked-data/def/patent/Publication |