Predicate |
Object |
assignee |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_3e035457406455ea05989c01cb90c8f1 |
classificationCPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12Q1-485 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N9-1205 |
classificationIPCAdditional |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07H21-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N1-20 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N9-12 |
classificationIPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12Q1-48 |
filingDate |
1999-12-14-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
grantDate |
2006-08-01-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
inventor |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_9d9f4cced7c79896fb3d52f72c25dabf http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_ca12ca6bda4d01a4d0870c2e15b27863 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_ae66f1a0a7f13606eefa98485de252e5 |
publicationDate |
2006-08-01-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
publicationNumber |
US-7083511-B1 |
titleOfInvention |
Methods |
abstract |
A method of activating serum and glucocorticoid-induced protein kinase (SGK) is provided wherein the SGK is phosphorylated. The SGK may be phosphorylated by PDK1 and/or a preparation containing PDK2 activity. A method of identifying a compound that modulates the activity of SGK is provided, wherein the activity of SGK is measured by measuring the phosphorylation by SGK of a polypeptide comprising an amino acid sequence corresponding to the consensus sequence (Arg/Lys; preferably Arg)-X-(X/Arg)-X-X-Ser/Thr)-Z wherein X indicates any amino acid, X/Arg indicates any amino acid, with a preference for arginine, and Z indicates that the amino acid residue is preferably a hydrophobic residue. The SGK may be activated by phosphorylation. |
isCitedBy |
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-2015211045-A1 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-101750460-B |
priorityDate |
1998-12-14-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
type |
http://data.epo.org/linked-data/def/patent/Publication |