| abstract |
Compounds of the formula (I) in which: R 1 is (CH 2 ) n Y; n is 1 or 2; Y is NHSO 2 R 2 or X 1 —W—X 2 —R 3 ; X 1 is O or NH; W is C═O, C═S, C═NH, or SO 2 ; X 2 is O or NH, provided that X 1 and X 2 are not both O; R 2 is C 1-10 alkyl; C 2-10 alkenyl; C 2-10 alkynyl; aryl; aryl-C 1-10 alkyl; aryl-C 2-10 alkenyl; aryl-C 2-10 alkynyl; C 3-8 cycloalkyl or C 3-8 -cycloalkyl-C 1-10 alkyl; and R 3 is hydrogen, C 1-10 alkyl; C 2-10 alkenyl; C 2-10 alkynyl; aryl; aryl-C 1-10 alkyl; aryl-C 2-10 alkenyl; aryl-C 2-10 alkynyl; C 3-8 cycloalkyl; or C 3-8 -cycloalkyl-C 1-10 alkyl; or a salt or ester thereof, modulate metabotropic glutamate receptor function and are useful in treating disorders of the central nervous system. |