| abstract |
A pharmaceutical composition comprising a compound of formula 1 n nwherein:n n is 1 or 2; R 1 is hydrogen, C 1 –C 4 -alkyl, halogen, OH, or —O—C 1 –C 4 -alkyl; R 2 is hydrogen, C 1 –C 4 -alkyl, halogen, OH, or —O—C 1 –C 4 -alkyl; R 3 is hydrogen, C 1 –C 4 -alkyl, OH, halogen, —O—C 1 –C 4 -alkyl, —O—C 1 –C 4 -alkylene-COOH, or —O—C 1 –C 4 -alkylene-CO—O—C 1 –C 4 -alkyl, orn nan acid addition salt thereof with a pharmacologically acceptable acid, or a solvate or hydrate thereof; andn na pharmaceutically acceptable excipient or carrier, and methods for using the pharmaceutical formulation in the treatment of chronic obstructive pulmonary disease (COPD). |