| Predicate |
Object |
| assignee |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_8d595ec481a2a081fed4aa2fd4ff52d8 |
| classificationCPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P35-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P33-02
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P43-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N9-1077
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K47-67
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K47-555
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P31-12
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P31-04
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/B82Y5-00 |
| classificationIPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P31-12
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K38-46
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P33-02
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-7064
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P35-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-706
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-7076
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P43-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N1-12
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N1-19
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K47-48
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N1-15
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N1-21
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K48-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N15-09
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K35-76
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07H19-16
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N15-85
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07H19-23
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N5-10
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N7-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N9-12
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N9-10
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P31-04 |
| filingDate |
2001-10-26-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate |
2006-05-02-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_24e1036f5fa81521763f5d88feeb44cb
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_a58ac0d8e248612b4515d46f0a9e68f0
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_2a66127fbf64782072a8443b699468fe
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_449d7e522dea36e16e60584368fdefdd |
| publicationDate |
2006-05-02-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber |
US-7037718-B2 |
| titleOfInvention |
Mutant purine nucleoside phosphorylase proteins and cellular delivery thereof |
| abstract |
The present invention provides a procaryotic host cell stably transformed or transfected by a vector including a DNA sequence encoding for mutant purine nucleoside phosphorylase or hydrolase. The transformed or transfected procaryotic host cell can be used in combination with a purine substrate to treat tumor cells and/or virally infected cells. The present invention provides nucleotide sequences encoding mutant E. coli derived purine nucleoside phosphorylase proteins which can be used in conjunction with an appropriate substrate to produce toxins which impair abnormal cell growth. The invention provides for delivery of the toxin by generation within target cells or by administration and delivery to the cells from without. |
| isCitedBy |
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-9605018-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-2010249068-A1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-9012427-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-2005214901-A1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-9394330-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-8916538-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-8980865-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-7488598-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-2008070860-A1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-8871737-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-9278990-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-9856284-B2 |
| priorityDate |
2001-10-26-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type |
http://data.epo.org/linked-data/def/patent/Publication |