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filingDate 2001-11-29-04:00^^<http://www.w3.org/2001/XMLSchema#date>
grantDate 2006-01-31-04:00^^<http://www.w3.org/2001/XMLSchema#date>
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publicationDate 2006-01-31-04:00^^<http://www.w3.org/2001/XMLSchema#date>
publicationNumber US-6991792-B2
titleOfInvention Prevention of autoimmune diabetes by immunogene therapy using recombinant vaccinia virus expressing glutamic acid decarboxylase
abstract A vaccine including recombinant vaccinia virus (ATCC VR-1354) having an inserted gene for coding glutamic acid decarboxylase is used for preventing type 1 diabetes mellitus. The glutamic acid decarboxylase expressed from the recombinant virus suppresses or tolerizes the autoreactive T cell, and induces immunological tolerance, thus effectively prevents or delays the development of type 1 diabetes mellitus.
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