| Predicate |
Object |
| assignee |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_ac36278fe42aa93b8f741c6b88b2848b |
| classificationCPCAdditional |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K47-12
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K47-02
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K47-26
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K47-183 |
| classificationCPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K38-484
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K38-4833
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K9-0019
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N9-6435
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12Y304-21007 |
| classificationIPCAdditional |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K47-02
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K47-18
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K47-12
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K47-26
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K38-00 |
| classificationIPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K38-48
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N9-68 |
| filingDate |
2002-05-10-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate |
2005-11-15-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_aa3a1b5bee88ac55e9e540e2046a84bf
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_56aab00bea61feafb5e36846f6c5dcc4
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_4cffabb4268adea2a3a63b76f16dcb33
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_e0eee8165db64c48ddb2a3f5ba71bd40
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_37aaa83bc79e773c38031e870934eb00 |
| publicationDate |
2005-11-15-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber |
US-6964764-B2 |
| titleOfInvention |
Method of thrombolysis by local delivery of reversibly inactivated acidified plasmin |
| abstract |
Methods of thrombolysis that allow the use of a fibrinolytic composition comprising reversibly inactivated acidified plasmin and the localized delivery of the plasmin to a vascular thrombotic occlusion are disclosed. Further disclosed is a method for administering a therapeutic dose of a fibrinolytic composition substantially free of plasminogen activator to a human or animal having a vascular thrombotic occlusion. The fibrinolytic composition includes a reversibly inactivated acidified plasmin substantially free of plasminogen activator. Intravascular catheter delivery of the fibrinolytic composition directly into or in the immediate vicinity of the thrombus is disclosed to minimize the systemic degradation of fibrin while retaining the maximum plasmin activity against the thrombus. |
| isCitedBy |
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-8512980-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-9121014-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-8182808-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-2007134230-A1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-2011003332-A1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-9226953-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-9644196-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-2003012777-A1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-8420079-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-7229810-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-9206410-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-8920794-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-8101394-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-9879246-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-2011201077-A1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-2002192794-A1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-8617863-B2 |
| priorityDate |
1999-11-13-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type |
http://data.epo.org/linked-data/def/patent/Publication |