Predicate |
Object |
assignee |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_a2919a384e8471477b61879f48477938 |
classificationCPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D211-22 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D211-32 |
classificationIPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D211-22 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D211-32 |
filingDate |
2003-11-17-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
grantDate |
2005-10-11-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
inventor |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_61b3bece71eebe04827938933b114421 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_8f3b60037d48a04b1a54208d103e9530 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_ef9ffc9ed76072d9ac1e5de564c68c24 |
publicationDate |
2005-10-11-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
publicationNumber |
US-6953856-B2 |
titleOfInvention |
Process for the preparation of 1-benzyl-4-(5,6-dimethoxy-1-indanon)-2-yl) methyl piperidine hydrochloride (Donepezil HCI) |
abstract |
A process for the preparation of 1-benzyl-4-[(5,6-dimethoxy-1-indanon)-2-yl] methyl piperidine hydrochloride (Donepezil HCl) is disclosed. 5,6-Dimethoxy-2-(pyridin-4-yl) methylene inda-1-one is hydrogenated with a noble metal catalyst or a non-oxide derivative of a noble metal catalyst in a solvent at 20-100° C. and 10-90 psi gauge pressure. The resulting 4-[(5,6-dimethoxy-1-indanon)-2-yl] methyl piperidine is alkylated with an alkylating agent in an organic solvent at 20-80° C. |
isCitedBy |
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-2011151359-A1 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-2006069125-A1 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-8987458-B2 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-2011077271-A1 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-7592459-B2 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-2010113793-A1 |
priorityDate |
2003-02-12-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
type |
http://data.epo.org/linked-data/def/patent/Publication |