http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-6949679-B1
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_e2613944636ab2fdf3f83ef2d4b304f0 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07C211-23 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07C211-22 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C211-23 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C211-13 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C211-22 |
| filingDate | 1998-04-21-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 2005-09-27-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_2adfc168018f7bb3379fc32187f6be0b http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_030a3ae3ae6436bdb7be40b741109eaf http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_53d8f1477fd7a510d6f7568706fc389e |
| publicationDate | 2005-09-27-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | US-6949679-B1 |
| titleOfInvention | Polyamine transport inhibitors |
| abstract | The present invention describes the design, synthesis and therapeutic use of a variety of novel inhibitors of polyamine transport. The main feature of this class of transport inhibitors is to incorporate a linker or side chain that prevents the uptake of polyamines and helps to conjugate polyamine analogs to form dimers with high inhibitory potency against polyamine uptake. These new compounds incorporate features that are designed to maximize their chemical and metabolic stability and their ability to bind to the polyamine transporter, and to minimize their toxicity by preventing their absorption by the cells. The purpose of such inhibitors is to prevent the uptake or salvaging of circulating polyamines by rapidly proliferating cells such as tumor cells, in order to potentiate the effect of therapeutic inhibitors of polyamine biosynthesis such as alpha-difluoromethylornithene. |
| isCitedBy | http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-2007004727-A1 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-7273888-B2 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-11752113-B2 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-2003130350-A1 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-2017165187-A1 |
| priorityDate | 1998-04-21-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 574.