| Predicate |
Object |
| assignee |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_945ae1209056dcb497edf108d69159da |
| classificationCPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D487-04
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-5377
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-541
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-519 |
| classificationIPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D487-04
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-5377
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-541
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-519 |
| filingDate |
2004-06-29-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate |
2005-09-20-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_617671d95cde126eb31e4628d37ec3e5
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_36eed40c95720096b46811ee612db9d7
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_9ecd1570d5f39bfbcc6c042330dee551 |
| publicationDate |
2005-09-20-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber |
US-6946554-B2 |
| titleOfInvention |
Process for the preparation of 9-deazaguanine derivatives |
| abstract |
Derivatives of 9-deazaguanine of the formula I: n n nare prepared by reacting an aldehyde or ketone of the formula II: n n nwith a dialkylaminomalonate to produce an enamine. The enamine is then reacted with a base to produce a pyrrole represented by the formula: n n nThe pyrrole is reacted with a compound represented by the formula R 3 OC(O)N═C(Z)NHC(O)OR 3 or a derivative of carbamimidoic acid to provide a protected guanidine compound. The guanidine compound is converted to the desired deazaguanine by reaction with 1) trifluoracetic acid or 2) C 1 -C 4 alkoxide or alkali metal or alkaline earth metal hydroxide followed by neutralization with an acid. |
| isCitedBy |
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-2012286415-A1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-9230924-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-9076892-B2 |
| priorityDate |
1996-12-10-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type |
http://data.epo.org/linked-data/def/patent/Publication |