http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-6943268-B2
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_8b4ee13af463c18c765406625e1c5d44 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-285 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-285 |
| filingDate | 2002-10-31-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 2005-09-13-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_0f2c0e7d2d3f9d8ffa19e7fa70215fd3 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_18c54e91742a3bcfbf31249dc0c61c30 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_018e16c84bcc10ed5744ef023bb19225 |
| publicationDate | 2005-09-13-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | US-6943268-B2 |
| titleOfInvention | Method for induction of L-selectin shedding |
| abstract | The invention provides anti-thiol reagents which inhibit enzyme activity of cell-associated protein disulfide isomerase (PDI) by oxidizing or blocking PDI active site vicinal thiol groups which normally participate in disulfide bond rearrangement of PDI substrates. Inhibition of this PDI function is particularly useful in blocking PDI-mediated entry of HIV or other virions into a host cell, as well as inhibiting lymphocyte traffic through the lymph nodes. The invention further provides an assay for the identification of such PDI inhibitors based on the discovery that inhibitors of the invention also induce shedding of the leucocyte L-selectin adhesion molecule. The invention additionally provides for suppression of inflammation and of lymph node entry by calmodulin antagonists that, like PDI inhibition, cause leukocyte L-selectin shedding. |
| priorityDate | 1999-11-10-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 414.