| abstract |
Described herein are compounds with affinity for the 5-HT 6 receptor, which have the general formula I: n n nwherein:n R represents a group of Formula II or Formula III; one of A, B D or E is a N atom, the remainder being CH groups; R 1 is selected from the group consisting of SO 2 Ar, C(O)Ar, CH 2 Ar and Ar; R 2 , R 3 and R 4 are independently selected from the group consisting of H and alkyl; β represents a single or double bond, with the proviso that there is only one double bond in the ring at a time; n is an integer of from 1-3; Z is selected from the group consisting of C, CH and N, provided that when βis a double bond, Z is C and when β is a single bond, Z is selected from CH and N; Ar is an optionally substituted aryl group;n nwith the proviso that when R is a group of Formula II, R 1 is SO 2 Ar.n nn Also described is the use of these compounds as pharmaceuticals to treat indications where inhibition of the 5-HT 6 receptor is implicated, such as schizophrenia. |