| abstract |
Compounds having the formula (I), n n nwherein R 3 is selected from H, OH and NH 2 ; R 30 is selected from ═O and ═S; W is —C(═O)—, —S(═O)—, or —S(O) 2 —; or W may be —CH 2 — if X is —C(═O)—; X is selected from —CH 2 —, —N(R 4 )—, and —O—, except that when W is —CH 2 —, X is —C(═O)—; Y is a bond or —C(R 40 )(R 45 )—; Q is a linker; Z is optionally substituted alkyl, alkenyl, alkynyl, cycloalkyl, aryl, heteroaryl, or heterocyclyl; and X 1 , X 2 , X 3 , X 4 , X 5 , X 6 , X 7 , X 8 , X 9 , X 10 and X 11 are selected such a tricyclic heteroaryl ring system is formed as further defined in the specification. |