http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-6875419-B2
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_d21cbff64022f95c237c0bd3ec8656ca |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P43-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K49-106 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P43-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K49-10 |
| filingDate | 2001-11-20-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 2005-04-05-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_6551fa5578df9a7d33e023face76fb13 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_14b9b949e53a3034ad410e51166df9fb http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_715c34b3f7479be6b8d13acf35245015 |
| publicationDate | 2005-04-05-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | US-6875419-B2 |
| titleOfInvention | Paramagnetic metal ion-based macrocyclic magnetization transfer contrast agents and method of use |
| abstract | The present invention is directed, in general, to contrast agents (CA), and methods and systems of using such agents for producing image contrast based on a magnetization transfer (MT) mechanism. The CA comprises a tetraazacyclododecane ligand having pendent arms R, R′, R″ and R′″ that are amides having a general formula: —CR 1 H—CO—NH—CH 2 —R 2 . R 1 includes organic substituents and R 2 is not hydrogen. A paramagnetic metal ion (M) is coordinated to the ligand. The method, comprises subjecting a CA, in a sample, to a radio frequency pulse. The CA has pendent arms R, R′, R″ and R′″ comprising organic substituents and the ligand further includes a M and a water molecule. A signal is obtained by applying a radio frequency pulse at a resonance frequency of the water molecule. The magnetic resonance system, comprises a magnetic resonance apparatus and the CA, the agent containing a ligand having the above described general formula. |
| isCitedBy | http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-2007258908-A1 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-2009142273-A1 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-2007237721-A1 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-2007069724-A1 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-7330028-B2 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-8003078-B2 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-7517701-B2 |
| priorityDate | 2000-11-20-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 93.