http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-6875418-B2
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_a4053f564c05390789cb2090d8fc0972 |
| classificationCPCAdditional | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61B5-4035 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K49-0004 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K49-00 |
| filingDate | 2002-06-19-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 2005-04-05-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_d54db8a873a87750ec91e77ca24a7913 |
| publicationDate | 2005-04-05-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | US-6875418-B2 |
| titleOfInvention | Method of early detection of Duchenne muscular dystrophy and other neuromuscular disease |
| abstract | The mdx mouse is a model of Duchenne muscular dystrophy. The present invention describes that mdx mice exhibited clinically relevant cardiac phenotypes. A non-invasive method of recording electrocardiograms (ECGs) was used to a study mdx mice (n=15) and control mice (n=15). The mdx mice had significant tachycardia, consistent with observations in patients with muscular dystrophy. Heart-rate was nearly 15% faster in mdx mice than control mice (P<0.01). ECGs revealed significant shortening of the rate-corrected QT interval duration (QTc) in mdx mice compared to control mice (P<0.05). PR interval duration were shorter at baseline in mdx compared to control mice (P<0.05). The muscarinic antagonist atropine significantly increased heart-rate and decreased PR interval duration in C57 mice. Paradoxically, atropine significantly decreased heart-rate and increased PR interval duration in all mdx mice. Pharmacological autonomic blockade and baroreflex sensitivity testing demonstrated an imbalance in autonomic nervous system modulation of heart-rate, with decreased parasympathetic activity and increased sympathetic activity in mdx mice. These electrocardiographic findings in dystrophin-deficient mice provide new bases for diagnosing, understanding, and treating patients with Duchenne muscular dystrophy. |
| isCitedBy | http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-7381185-B2 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-8641632-B2 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-8694086-B2 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-11103514-B2 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-2005251055-A1 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-2012190995-A1 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-2011137197-A1 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-2009076339-A1 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-8657756-B2 |
| priorityDate | 2001-06-19-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 314.