| Predicate |
Object |
| assignee |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_675890b893066a28f59cbf5b8aa780c5 |
| classificationCPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K49-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K49-1815 |
| classificationIPCAdditional |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/G01R33-483 |
| classificationIPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K49-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C69-675
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C67-303
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K49-18
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/G01R33-28 |
| filingDate |
2001-11-16-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate |
2005-03-29-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_8cf421865826e294d541857c461dd734
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_54bca1132a5cbb8bbb90c5b49eb7a7ed
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_6b170aa4c93b6b63abd5980964d353b7
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_f5af1ff5b41fe363b26b83a29926d7dd
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_8999dc15f1b91812252d39b726468b5d
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_b776690615da332b7049a01a3d555407 |
| publicationDate |
2005-03-29-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber |
US-6872380-B2 |
| titleOfInvention |
Process for preparation of MR contrast agents |
| abstract |
The present invention provides a process for the preparation of an MR contrast agent, said process comprising:n i) obtaining a solution in a solvent of a hydrogenatable, unsaturated substrate compound and a catalyst for the hydrogenation of said substrate compound; ii) introducing said solution in droplet form into a chamber containing hydrogen gas (H 2 ) enriched in para-hydrogen (p- 1 H 2 ) and/or ortho-deuterium (o- 2 H 2 ) whereby to hydrogenate said substrate to form a hydrogenated imaging agent; iii) optionally subjecting said hydrogenated imaging agent to a magnetic field having a field strength below earth's ambient field strength; iv) optionally dissolving said imaging agent in an aqueous medium; v) optionally separating said catalyst from the solution of said imaging agent in said aqueous medium; vi) optionally separating said solvent from the solution of said imaging agent in said aqueous medium; and vii) optionally freezing the solution of said imaging agent in said aqueous medium. |
| isCitedBy |
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/KR-101321862-B1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-2007136439-A3
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-10695448-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-2011095759-A1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-2015022204-A1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-2011178393-A1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-10369236-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-9207296-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-8766633-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-9566354-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-8961933-B2 |
| priorityDate |
1999-05-19-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type |
http://data.epo.org/linked-data/def/patent/Publication |