| abstract |
A compound of formula (I) and pharmaceutically acceptable salts, solvates and hydrolysable esters thereof n n nWhereinn R 1 and R 2 are independently H or C 1-3 alkyl or R 1 and R 2 which are bonded to the same carbon atom may together with the carbon atom to which they are bonded form a 3-5 membered cycloalkyl ring; X 1 represents O or S; Each R 3 , R 4 , R 8 and R 9 independently represents H, halogen, —CH 3 and —OCH 3 ; R 5 represents H or C 1-6 alkyl or R 4 and R 5 together form a 3-6 membered cycloalkyl ring. nn X 2 represents NH, NCH 3 or O;n One of Y and Z is N, and the other is O or S; R 6 represents phenyl or pyridyl (wherein the N is in position 2 or 3) and is optionally substituted by one or more halogen, CF 3 , C 1-6 straight or branched alkyl (optionally substituted by halogen), with the provision that when R 6 is pyridyl, the N is unsubstituted. nn R 7 represents C 1-6 alkyl, (optionally substituted by one or more halogens), —C 0-8 alkyl-5 membered heteroaryl, C 0-6 alkyl-(O) n -phenyl, wherein n is 0 or 1, with the proviso that when R 1 and R 2 are methyl, R 8 and R 9 are H, R 5 is H, then R 7 cannot be CH 3 or CF 3 . |