| Predicate |
Object |
| assignee |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_ef416fe4f66ebb1021cecfb0ba5ae45d |
| classificationCPCAdditional |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A01K2267-0337
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A01K2267-025
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A01K2267-0393
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A01K2267-0331
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A01K2217-075
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A01K2217-05
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A01K2227-105 |
| classificationCPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N15-8509
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A01K67-0271
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A01K67-0275
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A01K67-0276 |
| classificationIPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A01K67-027
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N15-85 |
| filingDate |
1999-06-24-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate |
2005-03-08-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_5e31dee8a7abac2da7a5a9212687a0ac
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_309bbfde171e8086fa009d51277ab4ee |
| publicationDate |
2005-03-08-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber |
US-6864402-B1 |
| titleOfInvention |
Chronic hepatitis virus infection and clonal hepatocellular carcinoma in mouse repopulated livers |
| abstract |
A method is provided for repopulating degenerated of immunetolerant mice which lack mature B and T lymphocytes with xenogenic mammalian hepatocytes, particularly primate hepatocytes to generate chimeric mice. In addition, a method of generating a human hepatitis virus-infected chimeric mouse is provided. A preferred xenogenic primate hepatocyte is derived from human, chimpanzee or baboon. These chimeric mice are useful in the investigation of host and viral mechanisms determining hepadnaviral persistence and hepatocarcinogenesis. Methods for monitoring the development of hepatitis and hepatocellular carcinoma as well as methods for testing and screening anti-viral and anti-cancer compounds with this model system are also provided. |
| isCitedBy |
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-11338065-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-2012048170-A2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-2003115616-A1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-7161057-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-8212106-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-2016130307-A1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-2006023593-A3
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-11617817-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-10004826-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-11266766-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-2011178004-A1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-2011167507-A1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-11324858-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-8445745-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-2004158885-A1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-10323068-B2 |
| priorityDate |
1998-09-18-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type |
http://data.epo.org/linked-data/def/patent/Publication |