http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-6825236-B2
Outgoing Links
Predicate | Object |
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assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_fc7a5f1d3a5847194265b272705f1941 http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_6db1542efe4f0101ccad244019d1a0bb |
classificationCPCAdditional | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07C2603-18 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07C2603-34 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07C2603-24 |
classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07C323-42 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07C323-41 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07C323-60 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07H5-06 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D295-15 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P35-00 |
classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D295-15 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C323-60 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C323-41 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07H5-06 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C323-42 |
filingDate | 2003-04-14-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
grantDate | 2004-11-30-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_e7d368c9ade8cf9ce201e28149575eeb |
publicationDate | 2004-11-30-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
publicationNumber | US-6825236-B2 |
titleOfInvention | Colchicine derivatives |
abstract | Certain N-deacetylcolchicine and N-deacetylthiocolchine derivatives are described wherein the 7-N position on the B ring is substituted with the group -C(O)-(CHR4)m-AR, wherein m is an integer of 0-10, A is S, O, N or a covalent bond; R1 is substituted phenyl or substituted benzoyl; optionally substituted cycloalkyl of 3-7 carbons; optionally substituted naphtyl; an optionally substituted imide ring; an optionally substituted 5 or 6 member heterocycle with at least one N, S, or O in the ring; or an optionally substituted fused heterocyclic or fused carboxyclic ring system; R2 (at the 2-position of the A ring) is methoxy, hydroxy, or methylenedioxy when taken together with R3; R3 (at the 3-position of the A ring) is methoxy, hydroxy, a monosaccharide radical, or is methylenedioxy when taken together with R2; and R4 is H or is H or methyl when m is 1. Also dimers of such compounds are disclosed. When combined with suitable pharmaceutical excipients, these compounds are useful for treating various types of cancer. |
priorityDate | 2003-04-14-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 476.